PTMA (prothymosin, alpha)
نویسندگان
چکیده
منابع مشابه
Molecular cloning of cDNA for human prothymosin alpha.
A cDNA library was constructed from human spleen mRNA and screened for clones containing cDNAs coding for prothymosin alpha. A clone containing a 503-base-pair insert including the entire coding sequence for the translated portion of the mRNA was isolated. The deduced amino acid sequence confirms and completes the partial sequence of human prothymosin alpha determined by protein sequencing meth...
متن کاملProthymosin alpha modulates the interaction of histone H1 with chromatin
Prothymosin alpha (ProTalpha) is an abundant acidic nuclear protein that may be involved in cell proliferation. In our search for its cellular partners, we have recently found that ProTalpha binds to linker histone H1. We now provide further evidence for the physiological relevance of this interaction by immunoisolation of a histone H1-ProTalpha complex from NIH 3T3 cell extracts. A detailed an...
متن کاملProthymosin-alpha and Ki-67 expression in pituitary adenomas.
INTRODUCTION Prothymosin alpha (PTMA), a nuclear oncoprotein involved in cell cycle regulation, is used as a prognostic marker in many cancers. The histopathology of pituitary carcinomas and locally invasive adenomas is indistinguishable from that of benign tumors. A new marker is needed to differentiate these lesions. We evaluated PTMA in pituitary adenomas to determine its usefulness as a pro...
متن کاملOverexpression of Prothymosin Alpha Predicts Poor Disease Outcome in Head and Neck Cancer
BACKGROUND In our recent study, tissue proteomic analysis of oral pre-malignant lesions (OPLs) and normal oral mucosa led to the identification of a panel of biomarkers, including prothymosin alpha (PTMA), to distinguish OPLs from histologically normal oral tissues. This study aimed to determine the clinical significance of PTMA overexpression in oral squamous cell hyperplasia, dysplasia and he...
متن کاملProthymosin Alpha (ProTα) and Thymosin Beta (Tβ): Conserved Immune- related Genes from Teleost to Mammals
Prothymosin alpha (ProTα) and thymosin beta (Tβ), members of the thymosin family, consist of a series of highly conserved peptides capable of stimulating immune responses in different species. Our recently published report discussed an issue of the conserved roles of ProTα b and Tβ-like (Tβ-l) in common carp (Cyprinus carpio L), which suggested that the highly-conserved carp ProTα b and Tβ-l ca...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44643